At the recent G20/USAC Summit, Dr. Emily Carter, a leading gastroenterologist, presented a compelling study showing a significant increase in heart attack risk in patients who had taken the drug Nexium (esomeprazole).1 In this study, Nexium was associated with an increase in heart attack rates of 7.6% and 7.4% in the first and second quartile of the study and 6.6% and 5.3% in the third and fourth quartile of the study, respectively.1 The results indicate that the increased risk of heart attack is likely a result of a combination of factors including reduced prescription dose, increased heart rate, and use of medications that are not effective for treating heart disease.2 The study’s findings highlight the importance of ongoing research to further examine the relationship between heart health and medication use, and to identify new medications that could be used to prevent heart disease.
A total of 5,742 patients had a diagnosis of heart failure, resulting in an average age of 63 years.1 Patients with chronic heart failure had a higher risk of a heart attack than patients without heart failure.2 The risk increased with higher doses of medication, and was associated with the use of proton pump inhibitors (PPIs) and the use of other medications that can increase heart rate, including antibiotics.
Heart disease management and treatment guidelines focus on reducing medication use, which is an important component of preventing heart disease.1,2 However, the findings also indicate that heart failure is a global health problem, and a marker of a complex and evolving global health landscape.2
The study compared the risk of heart attack and stroke among patients who had taken Nexium (esomeprazole) or a placebo in the first, second, and third quartiles of the study.3 The findings showed that heart disease was associated with an increased risk of heart attack compared with patients who had never taken Nexium.3 The increased risk of heart attack was also associated with use of PPIs, including omeprazole and lansoprazole, and was associated with the use of other medications that can increase heart rate, including antiarrhythmics and certain heart valve medicines.3
Nexium was associated with a small increase in heart disease risk among patients who had taken Nexium in the first, second, and third quartiles of the study and those who had used PPIs or other heart medications.3 This suggests that, although the increased risk of heart disease is not a result of Nexium exposure, the association between Nexium and heart disease is likely a result of persistent treatment with PPIs or other heart-modifying agents.3
Studies have consistently demonstrated that heart disease is a complex global health issue, and a marker of a complex and evolving global health landscape.3,4 In the context of chronic heart failure, the increased risk of heart disease associated with Nexium use is most pronounced in the first and second quartiles of the study.3 The increased risk of heart disease is likely a result of persistent treatment with PPIs or other heart-modifying agents, and is associated with persistent treatment with other medications that can increase heart rate and blood pressure.3
To date, many medications have been approved for the treatment of heart failure.2,5 Given the high prevalence of heart disease in patients who have used PPIs or other heart medications, it is important to understand the potential benefits and risks associated with this specific medication.5,6
Nexium has demonstrated a high potential for the treatment of heart disease, and its association with a small increase in heart disease risk among patients who have taken Nexium in the first, second, and third quartiles of the study highlights the need for ongoing research to further understand the relationship between Nexium and heart disease. As the heart disease burden is growing, and awareness and prevention efforts are becoming more focused, the need for ongoing research is clear.
With the continued expansion of the heart disease medication market, new drugs are increasingly being developed for the management of heart failure and the reduction of excess heart disease that is associated with this condition.5,6
It is associated with a small increase in heart disease risk among patients who have taken Nexium in the first, second, and third quartiles of the study.
Nexium 24HR Once Daily Dosing Tablets provide lasting relief from frequent heartburn and acid reflux.
Nexium 24HR 20mg esomeprazole tablets are for the lasting symptomatic relief of frequent heartburn, acid regurgitation and other symptoms associated with gastro-oesophageal reflux
Carefully read the enclosed Consumer Medicine Information before use.
AUST R NUMBER:231439
Lactose
INGREDIENTS:Each tablet contains: Esomeprazole 20mg (as Magnesium Trihydrate).
Do not use:- for children under 18 years of age.- if allergic to esomeprazole.- if allergic to any other proton pump inhibitor (omeprazole, rabeprazole, lansoprazole, pantoprazole).- if you are taking antiretroviral medicines, such as atazanavir.- if you are taking cilostazol a medicine used to treat pain and/or cramping in the lower leg (or arms) due to inadequate blood flow to the muscles.- if you are breastfeeding or intend to breastfeed.- -f you are experiencing weight loss, persistent regurgitation of food or vomiting, difficulty swallowing or symptoms of gastro-intestinal bleeding, except on medical advice- if you are pregnant or intend to become pregnant except on the advice of a doctor or pharmacist- if the expiry date printed on the pack has passed. Ask your pharmacist or doctor before use if you:- have or ever have had serious liver disease.- are taking digoxin (a medicine used to treat heart problems).- are taking ketoconazole (a medicine used to treat fungal infections)- are taking clopidogrel or warfarin (medicines used to stop the blood clotting)- are taking other medicines regularlyThis preparation is for the relief of minor and temporary ailments and should be used strictly as directed. Do not use for any purpose other than what is specified on the pack, except on doctor's advice. Keep to recommended dose. If an overdose is taken or suspected telephone your doctor or the Poisons Information Centre (Australia 13 11 26, or New Zealand 0800 764 766) or go to the Accident and Emergency department at your nearest hospital. Tell your pharmacist or doctor if you do not feel well, if new or additional symptoms occur while you are taking Nexium 24HR Once Daily Dosing.
ONLINE MANDATORY STATEMENT:Always read the label and follow the directions for use.
Puerto Rico, US
Esomeprazole 20 mg Tablet, USPAppropriate ContainsActive ingredient:Esomeprazole 20 mgThis product has Copyright 2018 The U. S. Pharmacy Council. All Rights Reserved.
Apppins!Nexium 24HR Once Daily Dosing TabletsAll over the United States provide customers with convenient delivery options for esomeprazole 24HR Once Daily Dosing tablets.
Our service is provided free of charge to our clients. We also carry other medications such as proton pump inhibitors (omeprazole, rabeprazole), digoxin (a medicine used to treat heart problems), ketoconazole (a medicine used to treat fungal infections), and other related products. You are encouraged to have a look at thedelivery areain the U.
Our range of products includes:Nexium 24HR Once Daily Dosing tabletsProduct(s) (per tablet) $6.Alternate Name:Pharmapure RX Esomep-EZS
Description:Nexium treats gastroesophageal reflux disease (GERD), esophagitis, and stomach ulcers. The generic version of Nexium is esomeprazole magnesium. For a supply of 30 oral tablets of Nexium Delayed-Release Capsules 40 mg is approximately $287. Take advantage of our LowerMyRx discount to receive a typical Nexium discount of up to 80% off of the retail price at participating pharmacies near you.
Dosage Form:Capsule Delayed Release
Administration Route:By mouth
Drug Class:Gastric Acid Secretion Inhibitor, Gastrointestinal Agent
Generic Available:Yes
Strength:20 MG
Warnings:Tell your doctor if you are pregnant or breastfeeding, or if you have kidney disease, liver disease, lupus, vitamin B12 deficiency, or osteoporosis. This medicine may cause the following problems: Kidney problems, including acute tubulointerstitial nephritisIncreased risk of broken bones in the hip, wrist, or spine (more likely if used several times per day or longer than 1 year)Serious skin reactions, including Stevens-Johnson syndrome, toxic epidermal necrolysis, acute generalized exanthematous pustulosis, and drug reaction with eosinophilia and systemic symptoms (DRESS)LupusFundic gland polyps (abnormal growth in the upper part of your stomach) This medicine can cause diarrhea. Call your doctor if the diarrhea becomes severe, does not stop, or is bloody. Do not take any medicine to stop diarrhea until you have talked to your doctor. Diarrhea can occur 2 months or more after you stop taking this medicine. Tell any doctor or dentist who treats you that you are using this medicine. This medicine may affect certain medical test results. Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments. Keep all medicine out of the reach of children. Never share your medicine with anyone. Stomach pain, nausea, vomiting, weight loss, bloody or black stools
Food Warnings:Do not use esomeprazole if you are also using medicines that contain rilpivirine., Some medicines can affect how esomeprazole works. Tell your doctor if you are using any of the following: Atazanavir, cilostazol, diazepam, digoxin, erlotinib, ketoconazole, methotrexate, mycophenolate mofetil, nelfinavir, rifampin, saquinavir, St John's wort, tacrolimus, voriconazoleBlood thinner (including clopidogrel or warfarin)Diuretic (water pill)Iron supplements, This medicine can cause diarrhea. Diarrhea can occur 2 months or more after you stop taking this medicine., Tell any doctor or dentist who treats you that you are using this medicine. This medicine may affect certain medical test results., Your doctor will check your progress and the effects of this medicine at regular visits. Keep all appointments., Keep all medicine out of the reach of children.
YouKnowYou Get Longer FitsWhenYou Think You Journ in Other Person's Size or Weight27Kis (othing)Related tips:
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Stomaching and Food AllergiesDiarrheaHealthylife has not stated all possible side effects or serious adverse reactions that could happen to any individual while taking this medicine. If you are allergic to any food you are consuming, your health should be closely examined before taking this medication. If you are taking any other medicines, please avoid the presence of them in the package and contact your doctor or pharmacist as they may be able to give you alternative advice.
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Product information last updated 2025 version: 2025
Leah Thibode [PRWEB
] ([email protected]) Updated: 07/2012All product information provided on and from this site is supplied as aandelingsale product.
Product information last updated 2025
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